Clinical staging to guide management of metabolic disorders and their sequelae: A European Atherosclerosis Society consensus statement
Featured Open Lecture: September-October 2026
The burden of obesity-related metabolic disease is rapidly increasing worldwide, driving a growing epidemic of cardiovascular, liver, kidney, and metabolic complications. Yet these conditions are too often approached in isolation, despite sharing interconnected pathophysiological pathways.
To address this challenge, the European Atherosclerosis Society (EAS) recently published a landmark consensus statement proposing a new clinical framework for understanding and managing systemic metabolic disorders, a multi-organ disease continuum linking dysfunctional adiposity, insulin resistance, dyslipidaemia, steatotic liver disease, kidney disease, heart failure, and atherosclerotic cardiovascular disease.
In this EAS Featured Open Lecture, we bring together two leading international experts and authors of the consensus report for an in-depth exploration of this emerging concept.
The lecture opens with Professor Kausik K. Ray, who will provide an overview of systemic metabolic disease, its clinical importance, and the rationale behind the proposed staging framework. He will discuss why a more integrated, multi-organ approach is needed to improve prevention and treatment strategies in cardiometabolic disease.
This will be followed by a deeper dive from Professor Stefano Romeo, who will explore the mechanistic pathways underlying systemic metabolic disorders and discuss how these insights may reshape future clinical management and research.
Together, these presentations provide a unique opportunity to understand one of the most important evolving paradigms in preventive cardiology and metabolic medicine
Link to the EAS Consensus Statement: Clinical staging to guide management of metabolic disorders and their sequelae: Clinical staging to guide management of metabolic disorders and their sequelae: a European Atherosclerosis Society consensus statement | European Heart Journal | Oxford Academic