Cardiovascular disease morbidity is associated with social deprivation in subjects with familial hypercholesterolaemia (FH): A retrospective cohort study of individuals with FH in UK primary care and the UK Simon Broome register, linked with national hospital records.

Social deprivation is associated with higher cardiovascular disease (CVD) morbidity and mortality. We examined whether this is also observed in people with FH.  We identified 4309 patients with FH in a GP-Based general population data base (CPRD) and 2956 in the Simon Broome UK FH register. Strikingly fewer individuals with FH were identified from lower socioeconomic groups, though the most deprived FH patients had the highest risk of CVD and mortality. In CPRD, this risk was largely explained by smoking and alcohol consumption, but not in the SB register. More effective strategies to detect FH and optimise risk factor management, are needed in lower socioeconomic groups.

• Atherosclerosis. 2025 Apr;403:119142.
• PMID: 40037086
• doi: 10.1016/j.atherosclerosis.2025.119142
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