Lipidomics, lipotoxicity and organic damage: Uncovering new lipid dependent pathophysiology pathways, biomarkers and therapy targets

In recent decades, clinical research on lipids and lipoproteins was predominantly focused on the cholesterol and triglyceride content of lipoproteins and their pathogenic contribution to atherosclerotic cardiovascular disease (ASCVD). This research strategy was very successful as it led to the development of prognostic algorithms and drugs that reduced the burden of ASCVD. However, both plasma and organs contain many other lipids including sterols, phospholipids, sphingolipids and fatty acids as well as many of their metabolic precursors and products. They are structurally very heterogeneous and fulfil a broad variety of functions including membrane and lipoprotein formation and signalling via cell surface or nuclear receptors. By altering cellular metabolism and function they exert positive and adverse effects on many organs and hence human health. The loss and gain of physiological and pathological functions, respectively, likely contribute to the pathogenesis of many diseases beyond ASCVD, such as diabetes mellitus, metabolic associated liver disease, heart failure, chronic kidney disease and neurodegenerative diseases.

The EAS LIPOTOXICITY COURSE aims to summarize and discuss our knowledge and perspectives on

  • the effect of lipid species on cell and organ function
  • the impact of lipotoxicity on organ damage
  • the contribution of metabolomics/lipidomics technologies toward better understanding of lipid metabolism, pathogenic mechanisms as well as identification of biomarkers and therapeutic targets

1: The Concept

Lecture by Jan Borén

2: The Tools

Lectures by Gerhard Liebisch, Xavier Correig, Núria Amigó and Matthew Conroy

3: The Molecules

Lectures by Thierry Durand, William J. Griffiths, Kathrin Engel and Thorsten Hornemann

4: The damage

Lectures by Pedro Rodrigues, Christoph Binder, Eoin Brennan, Christian Schulze and Pierre Maechler

5: The therapy

Lecture by Bart Staels