Lp(a) – Finding the right place

This is a lecture given by Professor Florian Kronenberg at the 91st EAS Congress 2023 in Mannheim Germany, May 21-24, 2023.

Florian Kronenberg is Professor and Head of the Institute of Genetic Epidemiology at the Medical University of Innsbruck, Austria. Among other scientific activities, Prof. Kronenberg has served as workgroup member on guideline and consensus initiatives on lipoproteins and atherosclerosis.

In his excellent and up-to-date overview, Professor Kronenberg presented data on the association of lipoprotein(a) (Lp(a)) with various cardiovascular disease (CVD) endpoints, including coronary artery disease, aortic valve stenosis, heart failure, ischemic stroke, peripheral arterial disease as well as total and cardiovascular mortality. He also presented data on the association of oxidized phospholipids with Lp(a), on the apolipoprotein (a) structural characteristics and isoforms as well as on the variability of Lp(a) within isoform groups. He next discussed the possible causal role of Lp(a) in CVD and the association of life-long genetic exposure to high Lp(a) levels with increased CVD risk. He continued his lecture presenting the consensus panel recommendation for managing high Lp(a) concentrations and discussed the emerging specific Lp(a)-lowering therapies targeting Lp(a) production. He also explained why the Lp(a) concentration in plasma should be measured, even if its levels could not be significantly reduced with existing hypolipidemic therapies.

It is a very important and comprehensive lecture you should not miss.